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Li Lab in single-molecule mechanobiology

Li Lab in single-molecule mechanobiology

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Our team

Our lab offers a unique opportunity to work within a collaborative, close-knit team focused on cutting-edge interdisciplinary research from single-molecule to multi-cellular studies. Our current projects span a variety of dynamic research areas, including:

We are always seeking exceptional students from diverse academic backgrounds — chemistry, physics, cell biology, and bioengineering — who are passionate about advancing scientific discovery. We welcome students from around the globe to contribute their unique perspectives and expertise. To learn more about our research and available opportunities, please contact Dr. Isaac Li at isaac.li@ubc.ca.

Principal Investigator

Isaac Li

Isaac Li

Associate Professor
CRC in sm-Biophysics+Mechanobiology
Michael Smith Scholar

Department of Chemistry | Biochemistry and Molecular Biology
The University of British Columbia - Okanagan Campus

Postdoc - UIUC (Biophysics)
PhD - University of Toronto (Chemistry)
MASc - University of Toronto (BME)
BASc - University of Toronto (Eng Sci)

Contact info

Office: FIP 343 | 250.807.8069
Lab: FIP 378 | 250.807.9825
Address: 3247 University Way, Kelowna, BC V1V1V7
Email: isaac.li@ubc.ca

Postdocs

Minh Thang Nguyen

Minh Thang Nguyen

Postdoc (2024.8-)

Postdoc - Korea University
PhD - Kyoto University

Research interests: DNA nanostructures, DNA-PAINT, and diaganostic assays

Postdoc position & resources

We are currently only considering postdoc candidate with fellowships. We generally seek postdocs with background in biophysics, physical chemistry or cell biology. Please contact isaac.li@ubc.ca directly for inquiries.

Postdoc funding opportunities:

Graduate Students

Adam Yasunaga

Adam Yasunaga

PhD in Biochemistry (2019.9-)
Honours in Biochemistry (2018-2019)

BSc - UBC (Biochem)

Research interests: rolling adhesion, DNA flow-stretch, single-molecule force and fluorescence

Liubov Frolova

Liubov Frolova

PhD in Biochemistry (2021.1-)

MSc - Moscow State University (Nanobiotech)

Research interests: exosome biogenesis and bioengineering

Dyuti Raghu

Dyuti Raghu

PhD in Chemistry (2022.9-)
Honours in Biochemistry (2021-2022)
IURA (2021)

BSc - UBC (Biochem)

Research interests: DNA conformational kinetics, super-resolution functional imaging

Micah Yang

Micah Yang

PhD in Biochemistry (2022.9-)
Honours in Biochemistry (2021-2022)
Directed Studies (2020-2021)
USRA (2021, 2022)

BSc - UBC (Biochem)

Research interests: single-molecule force spectroscopy, optical tweezers and DNA nanomechanics

David Bakker

David Bakker

PhD in Biochemistry (2022.9-)
Honours in Biochemistry (2020-2021)

BSc - UBC (Biochems)

Research interests: single-molecule force spectroscopy, optical tweezers and DNA knots

Shilong Pan

Shilong Pan

MSc in Chemistry (2022.9-)
Honours in Biochemistry (2021-2022)
USRA (2022)

BSc - UBC (Biochem)

Research interests: nanoparticle sizing and exosome characterization

Irving Zhang

Irving Zhang

MSc in Biochemistry (2023.9-)

BSc - UBC (Biochem)

Research interests: DNA tension probes, mechanobiology

Hengfeng Jiang

Hengfeng Jiang

PhD in Chemistry (2025.1-)

MSc/BEng - SUSTech (Chemistry, Materials Science)

Research interests: DNA + single-molecule force

Graduate position & resources

If you are passionate about creative, hands-on, and multidisciplinary research, this opportunity is for you. We welcome students from all backgrounds, particularly those with a strong track record in the physical sciences or engineering. In my lab, you will have the chance to develop diverse skills in areas such as single-molecule techniques (fluorescence and force), super-resolution microscopy, DNA nanotechnology, instrumentation, and bioengineering of cell behaviour. Interested students should contact Isaac Li, and apply through the College of Graduate Studies at UBC Okanagan.

College of Graduate Studies (CoGS):
Grad student resources on applications, academics, deadlines, thesis and defence, awards and financial support, and various forms.

Undergraduate Students

Ryan Riopel

Ryan Riopel

Honours in Biochemistry (2024.9-)
Directed Studies (2023-2024)
USRA, URA (2023, 2024)

Research interests: DNA flow-stretch, single-molecule force and fluorescence

Kiera McAnerney

Kiera McAnerney

Directed Studies (2024.9-)
USRA (2024)

Research interests: DNA flow-stretch, single-molecule force and fluorescence

Danika Strelaeff

Danika Strelaeff

Honours in Biochemistry (2024.9-)
co-supervised with Dr. Thuy Dang

Research interests: molecular biology, cell surface display

Undergraduate positions & resources

We offer several undergraduate research positions each year. Students usually begin in the summer, funded through programs such as the Science URA, NSERC USRA, or Work-Study, and often continue with a 2-term Honours Thesis or Directed Studies. The application deadline for summer research programs is typically in January. For more information or to discuss potential opportunities, please contact Isaac Li

Honours Thesis & Directed Studies:
Students wishing to do Honours Thesis / Directed Studies (CHEM448/449 & BIOC448/449) should contact me directly.

Summer research:
Students at UBC Okanagan can apply for URA and NSERC-USRA.

Work-Study program:
We have N Work-Study positions open for 2022 summer and fall terms. Please check the UBC student job board.

International students:
Please check out Mitac Globalink Research Internship.

Alumni